Frontiers in Neurology (Jul 2023)

Evaluation of iron deposition in the motor CSTC loop of a Chinese family with paroxysmal kinesigenic dyskinesia using quantitative susceptibility mapping

  • Fangfang Xie,
  • Ting Mao,
  • Jingyi Tang,
  • Linmei Zhao,
  • Jiuqing Guo,
  • Huashan Lin,
  • Dongcui Wang,
  • Dongcui Wang,
  • Gaofeng Zhou,
  • Gaofeng Zhou

DOI
https://doi.org/10.3389/fneur.2023.1164600
Journal volume & issue
Vol. 14

Abstract

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IntroductionPrevious studies have revealed structural, functional, and metabolic changes in brain regions inside the cortico-striatal-thalamo-cortical (CSTC) loop in patients with paroxysmal kinesigenic dyskinesia (PKD), whereas no quantitative susceptibility mapping (QSM)-related studies have explored brain iron deposition in these areas.MethodsA total of eight familial PKD patients and 10 of their healthy family members (normal controls) were recruited and underwent QSM on a 3T magnetic resonance imaging system. Magnetic susceptibility maps were reconstructed using a multi-scale dipole inversion algorithm. Thereafter, we specifically analyzed changes in local mean susceptibility values in cortical regions and subcortical nuclei inside the motor CSTC loop.ResultsCompared with normal controls, PKD patients had altered brain iron levels. In the cortical gray matter area involved with the motor CSTC loop, susceptibility values were generally elevated, especially in the bilateral M1 and PMv regions. In the subcortical nuclei regions involved with the motor CSTC loop, susceptibility values were generally lower, especially in the bilateral substantia nigra regions.ConclusionOur results provide new evidence for the neuropathogenesis of PKD and suggest that an imbalance in brain iron levels may play a role in PKD.

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