Nature Communications (Aug 2020)

Dynamic remodelling of the human host cell proteome and phosphoproteome upon enterovirus infection

  • Piero Giansanti,
  • Jeroen R. P. M. Strating,
  • Kyra A. Y. Defourny,
  • Ieva Cesonyte,
  • Alexia M. S. Bottino,
  • Harm Post,
  • Ekaterina G. Viktorova,
  • Vien Quang Tri Ho,
  • Martijn A. Langereis,
  • George A. Belov,
  • Esther N. M. Nolte-‘t Hoen,
  • Albert J. R. Heck,
  • Frank J. M. van Kuppeveld

DOI
https://doi.org/10.1038/s41467-020-18168-3
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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Here, Giansanti et al. perform a system-wide and time-resolved characterization of the changes in the host cell proteome and phosphoproteome of cells infected with the enterovirus coxsackievirus B3 during a full round of replication and identify mTORC1 signalling as a major regulation network during virus infection.