Nature Communications (Dec 2022)
An NKX-COUP-TFII morphogenetic code directs mucosal endothelial addressin expression
- Thanh Theresa Dinh,
- Menglan Xiang,
- Anusha Rajaraman,
- Yongzhi Wang,
- Nicole Salazar,
- Yu Zhu,
- Walter Roper,
- Siyeon Rhee,
- Kevin Brulois,
- Ed O’Hara,
- Helena Kiefel,
- Truc M. Dinh,
- Yuhan Bi,
- Dalila Gonzalez,
- Evan P. Bao,
- Kristy Red-Horse,
- Peter Balogh,
- Fanni Gábris,
- Balázs Gaszner,
- Gergely Berta,
- Junliang Pan,
- Eugene C. Butcher
Affiliations
- Thanh Theresa Dinh
- Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine
- Menglan Xiang
- Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine
- Anusha Rajaraman
- Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine
- Yongzhi Wang
- Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine
- Nicole Salazar
- Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine
- Yu Zhu
- Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine
- Walter Roper
- Columbia University Vagelos College of Physicians and Surgeons
- Siyeon Rhee
- Department of Biology, Stanford University
- Kevin Brulois
- Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine
- Ed O’Hara
- Palo Alto Veterans Institute for Research
- Helena Kiefel
- Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine
- Truc M. Dinh
- Palo Alto Veterans Institute for Research
- Yuhan Bi
- Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine
- Dalila Gonzalez
- University of California, San Diego
- Evan P. Bao
- Palo Alto Veterans Institute for Research
- Kristy Red-Horse
- Department of Biology, Stanford University
- Peter Balogh
- Department of Immunology and Biotechnology, University of Pécs Medical School
- Fanni Gábris
- Department of Immunology and Biotechnology, University of Pécs Medical School
- Balázs Gaszner
- Department of Anatomy, University of Pécs Medical School
- Gergely Berta
- Department of Medical Biology and Central Electron Microscopy Laboratory, University of Pécs Medical School
- Junliang Pan
- Palo Alto Veterans Institute for Research
- Eugene C. Butcher
- Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-34991-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Vascular addressins control lymphocyte homing, thus regulating immunity and inflammation, but how addressin expression is patterned remains unknown. Here the authors identify composite DNA elements (NCCEs) that bind NKX2 homeodomain proteins cooperatively with COUP-TFII to define a morphogenetic code that targets transcription of mucosal vascular addressins.
