Nature Communications (Dec 2020)
Blood and lymphatic systems are segregated by the FLCN tumor suppressor
- Ikue Tai-Nagara,
- Yukiko Hasumi,
- Dai Kusumoto,
- Hisashi Hasumi,
- Keisuke Okabe,
- Tomofumi Ando,
- Fumio Matsuzaki,
- Fumiko Itoh,
- Hideyuki Saya,
- Chang Liu,
- Wenling Li,
- Yoh-suke Mukouyama,
- W. Marston Linehan,
- Xinyi Liu,
- Masanori Hirashima,
- Yutaka Suzuki,
- Shintaro Funasaki,
- Yorifumi Satou,
- Mitsuko Furuya,
- Masaya Baba,
- Yoshiaki Kubota
Affiliations
- Ikue Tai-Nagara
- Department of Anatomy, Keio University School of Medicine
- Yukiko Hasumi
- Department of Ophthalmology, Yokohama City University Graduate School of Medicine
- Dai Kusumoto
- Department of Cardiology, Keio University School of Medicine
- Hisashi Hasumi
- Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Keisuke Okabe
- Department of Anatomy, Keio University School of Medicine
- Tomofumi Ando
- Department of Anatomy, Keio University School of Medicine
- Fumio Matsuzaki
- Laboratory for Cell Asymmetry, RIKEN Center for Biosystems Dynamics Research
- Fumiko Itoh
- Laboratory of Cardiovascular Medicine, Tokyo University of Pharmacy and Life Sciences
- Hideyuki Saya
- Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine
- Chang Liu
- Laboratory of Stem Cell and Neuro-Vascular Biology, Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health
- Wenling Li
- Laboratory of Stem Cell and Neuro-Vascular Biology, Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health
- Yoh-suke Mukouyama
- Laboratory of Stem Cell and Neuro-Vascular Biology, Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health
- W. Marston Linehan
- Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Xinyi Liu
- Division of Pharmacology, Niigata University Graduate School of Medical and Dental Sciences
- Masanori Hirashima
- Division of Pharmacology, Niigata University Graduate School of Medical and Dental Sciences
- Yutaka Suzuki
- Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo
- Shintaro Funasaki
- Laboratory of Cancer Metabolism, International Research Center for Medical Sciences, Kumamoto University
- Yorifumi Satou
- Division of Genomics and Transcriptomics Joint Research Center for Human Retrovirus Infection, Kumamoto and Kagoshima Universities
- Mitsuko Furuya
- Department of Molecular Pathology, Yokohama City University Graduate School of Medicine
- Masaya Baba
- Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Yoshiaki Kubota
- Department of Anatomy, Keio University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-20156-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Blood and lymphatic vessels bear a strong resemblance but do not share a lumen, thus maintaining their distinct functions. Here, the authors describe that Folliculin, a tumor suppressor, prevents the fusion of these vessels during development by limiting the plasticity of venous and lymphatic endothelial cells.
