Myelodysplastic syndrome-associated spliceosome gene mutations enhance innate immune signaling

• Daniel A. Pollyea,
• Chelsea Harris,
• Jennifer L. Rabe,
• Brenna R. Hedin,
• Lesly De Arras,
• Sigrid Katz,
• Emily Wheeler,
• Rafael Bejar,
• Matthew J. Walter,
• Craig T. Jordan,
• Eric M. Pietras,
• Scott Alper

Affiliations

Daniel A. Pollyea

Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO

Chelsea Harris

Department of Biomedical Research, National Jewish Health, Denver, CO;Center for Genes, Environment and Health, National Jewish Health, Denver, CO

Jennifer L. Rabe

Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO

Brenna R. Hedin

Department of Biomedical Research, National Jewish Health, Denver, CO;Center for Genes, Environment and Health, National Jewish Health, Denver, CO

Lesly De Arras

Center for Genes, Environment and Health, National Jewish Health, Denver, CO

Sigrid Katz

Division of Hematology and Oncology, University of California, San Diego, La Jolla, CA

Emily Wheeler

Division of Hematology and Oncology, University of California, San Diego, La Jolla, CA

Rafael Bejar

Division of Hematology and Oncology, University of California, San Diego, La Jolla, CA

Matthew J. Walter

Division of Oncology, Department of Medicine, Washington University, St. Louis, MO

Craig T. Jordan

Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO

Eric M. Pietras

Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO

Scott Alper

Department of Biomedical Research, National Jewish Health, Denver, CO;Center for Genes, Environment and Health, National Jewish Health, Denver, CO;Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA