Pathogens (Sep 2022)

Characteristics of COVID-19 Infection in a Hospitalized Autoimmune Hepatitis Patient

  • Vanessa Duarte da Costa,
  • Wilian Jean Wiggers,
  • Claudia Alexandra Pontes Ivantes,
  • Rodrigo Jardim Monteiro da Fonseca,
  • Alberto Martín Rivera Dávila,
  • Otacilio C. Moreira,
  • Beatriz Iandra da Silva Ferreira,
  • Vanessa Salete de Paula,
  • Lucas Lima da Silva,
  • Alanna Calheiros Santos,
  • Livia Melo Villar

DOI
https://doi.org/10.3390/pathogens11091054
Journal volume & issue
Vol. 11, no. 9
p. 1054

Abstract

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The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has become a major public health worldwide. Hepatic dysfunction has been seen in patients with COVID-19 and could be related to a viral cytopathic effect, an exacerbated immune reaction, or drug-induced liver damage. Currently, routine modification of immunosuppressive therapy in patients with autoimmune hepatitis (AIH) before and after SARS-CoV-2 infection remains an important topic to be discussed. However, there is little evidence about this thematic to support any recommendation. Here, we described a case report in which the use of an immunosuppressive drug by a patient with diagnosed AIH might have influenced the COVID-19 clinical course with altered laboratory hematological and biochemical parameters during infection.

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