Anti-inflammatory effects of ruxolitinib on chronic neutrophilic leukemia harboring CSF3R-T618I mutation with bilateral renal abscesses

Naohi Sahara; Kazuaki Yokoyama; Takashi Matsunaga; Shinsuke Kitahara; Tomoki Fujii; Seiichiro Kobayashi; Nozomi Yusa; Eigo Shimizu; Seiya Imoto; Arinobu Tojo; Nobuhiro Ohno

Leukemia Research Reports (Jan 2022)

Anti-inflammatory effects of ruxolitinib on chronic neutrophilic leukemia harboring CSF3R-T618I mutation with bilateral renal abscesses

Naohi Sahara,
Kazuaki Yokoyama,
Takashi Matsunaga,
Shinsuke Kitahara,
Tomoki Fujii,
Seiichiro Kobayashi,
Nozomi Yusa,
Eigo Shimizu,
Seiya Imoto,
Arinobu Tojo,
Nobuhiro Ohno

Affiliations

Naohi Sahara: Department of Hematology, Kanto Rosai Hospital, 1-1 Kizukisumiyoshicho, Nakahara-ku, 211-8510 Kawasaki city, Kanagawa, Japan; Corresponding author at: Department of Hematology, Kanto Rosai Hospital, 1-1 Kizukisumiyoshicho, Nakahara-ku, 211-8510 Kawasaki city, Kanagawa, Japan.
Kazuaki Yokoyama: Department of Hematology/Oncology, Research Hospital, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108-8639 Tokyo, Japan; Corresponding author at: Department of Hematology/Oncology, Research Hospital, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108-8639 Tokyo, Japan.
Takashi Matsunaga: Department of Hematology, Kanto Rosai Hospital, 1-1 Kizukisumiyoshicho, Nakahara-ku, 211-8510 Kawasaki city, Kanagawa, Japan
Shinsuke Kitahara: Department of Clinical Oncology, Kanto Rosai Hospital, 1-1 Kizukisumiyoshicho, Nakahara-ku, Kawasaki city, 211-8510 Kanagawa, Japan
Tomoki Fujii: Department of Hematology, Kanto Rosai Hospital, 1-1 Kizukisumiyoshicho, Nakahara-ku, 211-8510 Kawasaki city, Kanagawa, Japan; Department of Clinical Oncology, Kanto Rosai Hospital, 1-1 Kizukisumiyoshicho, Nakahara-ku, Kawasaki city, 211-8510 Kanagawa, Japan
Seiichiro Kobayashi: Department of Hematology, Kanto Rosai Hospital, 1-1 Kizukisumiyoshicho, Nakahara-ku, 211-8510 Kawasaki city, Kanagawa, Japan
Nozomi Yusa: Department of Applied Genomics, Research Hospital, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108-8639 Tokyo, Japan
Eigo Shimizu: Health Intelligence Center, Institute of Medical Science, Research Hospital, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108-8639 Tokyo, Japan
Seiya Imoto: Health Intelligence Center, Institute of Medical Science, Research Hospital, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108-8639 Tokyo, Japan
Arinobu Tojo: Department of Hematology/Oncology, Research Hospital, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108-8639 Tokyo, Japan
Nobuhiro Ohno: Department of Hematology, Kanto Rosai Hospital, 1-1 Kizukisumiyoshicho, Nakahara-ku, 211-8510 Kawasaki city, Kanagawa, Japan

Journal volume & issue: Vol. 18
p. 100348

Abstract

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Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm (MPN) characterized by sustained mature neutrophilic leukocytosis. Recently, presence of colony-stimulating factor 3 receptor (CSF3R) mutations has been added to the diagnostic criteria for CNL. Anti-inflammatory effects of the JAK1/2 inhibitor ruxolitinib relieve constitutional symptoms associated with MPN, such as fatigue, night sweats, and fever. We present a case of CNL harboring CSF3R-T618I mutation exacerbated by concomitant bilateral renal abscesses, which was refractory to antibiotics, at the time of initial diagnosis. In this case, ruxolitinib rapidly improved not only CNL but the infection, due to its anti-inflammatory potency.

Published in Leukemia Research Reports

ISSN: 2213-0489 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.journals.elsevier.com/leukemia-research-reports/

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