Nature Communications (Jan 2018)
Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling
- Josephine Elia,
- Grace Ungal,
- Charlly Kao,
- Alexander Ambrosini,
- Nilsa De Jesus-Rosario,
- Lene Larsen,
- Rosetta Chiavacci,
- Tiancheng Wang,
- Christine Kurian,
- Kanani Titchen,
- Brian Sykes,
- Sharon Hwang,
- Bhumi Kumar,
- Jacqueline Potts,
- Joshua Davis,
- Jeffrey Malatack,
- Emma Slattery,
- Ganesh Moorthy,
- Athena Zuppa,
- Andrew Weller,
- Enda Byrne,
- Yun R. Li,
- Walter K. Kraft,
- Hakon Hakonarson
Affiliations
- Josephine Elia
- Nemours, du Pont Hospital for Children
- Grace Ungal
- Drexel University College of Medicine
- Charlly Kao
- The Center for Applied Genomics, The Children’s Hospital of Philadelphia
- Alexander Ambrosini
- University of Pennsylvania
- Nilsa De Jesus-Rosario
- Department of Psychiatry Sidney Kimmel Medical College of Thomas Jefferson University
- Lene Larsen
- Department of Psychiatry Sidney Kimmel Medical College of Thomas Jefferson University
- Rosetta Chiavacci
- The Center for Applied Genomics, The Children’s Hospital of Philadelphia
- Tiancheng Wang
- The Center for Applied Genomics, The Children’s Hospital of Philadelphia
- Christine Kurian
- Department of Pediatrics Sidney Kimmel Medical College of Thomas Jefferson University
- Kanani Titchen
- Nemours, du Pont Hospital for Children
- Brian Sykes
- Nemours, du Pont Hospital for Children
- Sharon Hwang
- Nemours, du Pont Hospital for Children
- Bhumi Kumar
- Nemours, du Pont Hospital for Children
- Jacqueline Potts
- Department of Pediatrics Sidney Kimmel Medical College of Thomas Jefferson University
- Joshua Davis
- Nemours, du Pont Hospital for Children
- Jeffrey Malatack
- Nemours, du Pont Hospital for Children
- Emma Slattery
- Department of Pediatrics Sidney Kimmel Medical College of Thomas Jefferson University
- Ganesh Moorthy
- Department of Pediatrics Perelman School of Medicine, University of Pennsylvania
- Athena Zuppa
- Department of Pediatrics Perelman School of Medicine, University of Pennsylvania
- Andrew Weller
- Department of Psychiatry Sidney Kimmel Medical College of Thomas Jefferson University
- Enda Byrne
- The Center for Applied Genomics, The Children’s Hospital of Philadelphia
- Yun R. Li
- The Center for Applied Genomics, The Children’s Hospital of Philadelphia
- Walter K. Kraft
- Department of Pediatrics Sidney Kimmel Medical College of Thomas Jefferson University
- Hakon Hakonarson
- The Center for Applied Genomics, The Children’s Hospital of Philadelphia
- DOI
- https://doi.org/10.1038/s41467-017-02244-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 9
Abstract
Stimulant drugs are most commonly used to treat ADHD. Here, the authors demonstrate that in adolescents with ADHD who also have genetic variation in genes impacting metabotropic glutamate signaling, the non-stimulant mGluR activator fasoracetam is well tolerated and may be beneficial in alleviating symptoms of this disease.
