Neural Regeneration Research (Jan 2015)
A 2-year follow-up survey of 523 cases with peripheral nerve injuries caused by the earthquake in Wenchuan, China
- Chun-qing He,
- Li-hai Zhang,
- Xian-fei Liu,
- Pei-fu Tang
Affiliations
- Chun-qing He
- Li-hai Zhang
- Xian-fei Liu
- Pei-fu Tang
- DOI
- https://doi.org/10.4103/1673-5374.152379
- Journal volume & issue
-
Vol. 10,
no. 2
pp. 252 – 259
Abstract
We performed a 2-year follow-up survey of 523 patients with peripheral nerve injuries caused by the earthquake in Wenchuan, Sichuan Province, China. Nerve injuries were classified into three types: type I injuries were nerve transection injuries, type II injuries were nerve compression injuries, and type III injuries displayed no direct neurological dysfunction due to trauma. In this study, 31 patients had type I injuries involving 41 nerves, 419 had type II injuries involving 823 nerves, and 73 had type III injuries involving 150 nerves. Twenty-two patients had open transection nerve injury. The restoration of peripheral nerve function after different treatments was evaluated. Surgical decompression favorably affected nerve recovery. Physiotherapy was effective for type I and type II nerve injuries, but not substantially for type III nerve injury. Pharmacotherapy had little effect on type II or type III nerve injuries. Targeted decompression surgery and physiotherapy contributed to the effective treatment of nerve transection and compression injuries. The Louisiana State University Health Sciences Center score for nerve injury severity declined with increasing duration of being trapped. In the first year after treatment, the Louisiana State University Health Sciences Center score for grades 3 to 5 nerve injury increased by 28.2% to 81.8%. If scores were still poor (0 or 1) after a 1-year period of treatment, further treatment was not effective.
Keywords
- Alzheimer′s disease
- amyloid-β
- astrocytes
- Ca 2+
- calcilytic
- calcium-sensing receptor
- nitromemantine
- NPS 2143
- α7-nicotinic acetylcholine receptor
- nerve regeneration
- spinal cord injury
- surgical decompression
- tumor necrosis factor α
- cell apoptosis
- neurological function
- neural regeneration
- nerve regeneration
- spinal cord injury
- contusion
- Nogo-A
- axon growth
- immunohistochemistry
- fluorescent quantitative PCR
- neural regeneration
- nerve regeneration
- spinal cord injury
- Schwann cells
- cell transplantation
- edaravone
- motor function
- electrophysiological function
- neural regeneration
- nerve regeneration
- electroacupuncture
- intervertebral disc
- blood circulation
- inflammation
- neuroprotection
- motor function
- neurons
- NSFC grants
- neural regeneration
- nerve regeneration
- astrocytoma
- mice
- immunodeficiency (BALB/c) mice
- Notch
- nestin
- glial fibrillary acidic protein
- CD133
- spinal cord
- brain
- MRI
- neural regeneration
- nerve regeneration
- earthquake
- peripheral nerve injury
- LSUHSC score
- compartment syndrome
- surgery therapy
- physiotherapy
- nerve decompression
- neural regeneration