Laser-Synthesized SERS Substrates as Sensors toward Therapeutic Drug Monitoring

Abstract

The synthesis by pulsed laser ablation and the characterization of both the surface nanostructure and the optical properties of noble metal nanoparticle-based substrates used in Surface Enhanced Raman Spectroscopy are discussed with reference to application in the detection of anti-epileptic drugs. Results on two representative drugs, namely Carbamazepine and Perampanel, are critically addressed.

Keywords

• noble metal nanoparticles
• pulsed laser ablation
• surface enhanced Raman spectroscopy
• antiepileptic drugs