Nature Communications (Apr 2023)
MOZ/ENL complex is a recruiting factor of leukemic AF10 fusion proteins
Abstract
Altered transcriptional machinery promotes aberrant self-renewal of non-stem hematopoietic progenitors. Here the authors show that AF10 fusion proteins cause aberrant self-renewal via ENL, which promotes leukemic transformation by binding to MOZ/MORF lysine acetyltransferases