Frontiers in Molecular Neuroscience (Feb 2023)
MicroRNAs in spinal cord injury: A narrative review
- Chunjia Zhang,
- Chunjia Zhang,
- Chunjia Zhang,
- Chunjia Zhang,
- Chunjia Zhang,
- Zuliyaer Talifu,
- Zuliyaer Talifu,
- Zuliyaer Talifu,
- Zuliyaer Talifu,
- Zuliyaer Talifu,
- Zuliyaer Talifu,
- Xin Xu,
- Xin Xu,
- Xin Xu,
- Xin Xu,
- Xin Xu,
- Wubo Liu,
- Wubo Liu,
- Wubo Liu,
- Wubo Liu,
- Wubo Liu,
- Wubo Liu,
- Wubo Liu,
- Han Ke,
- Han Ke,
- Han Ke,
- Han Ke,
- Han Ke,
- Han Ke,
- Han Ke,
- Yunzhu Pan,
- Yunzhu Pan,
- Yunzhu Pan,
- Yunzhu Pan,
- Yunzhu Pan,
- Yunzhu Pan,
- Yan Li,
- Yan Li,
- Yan Li,
- Fan Bai,
- Fan Bai,
- Fan Bai,
- Yingli Jing,
- Yingli Jing,
- Yingli Jing,
- Zihan Li,
- Zihan Li,
- Zihan Li,
- Zehui Li,
- Zehui Li,
- Zehui Li,
- Zehui Li,
- Zehui Li,
- Degang Yang,
- Degang Yang,
- Degang Yang,
- Degang Yang,
- Degang Yang,
- Feng Gao,
- Feng Gao,
- Feng Gao,
- Feng Gao,
- Feng Gao,
- Liangjie Du,
- Liangjie Du,
- Liangjie Du,
- Liangjie Du,
- Liangjie Du,
- Jianjun Li,
- Jianjun Li,
- Jianjun Li,
- Jianjun Li,
- Jianjun Li,
- Jianjun Li,
- Jianjun Li,
- Yan Yu,
- Yan Yu,
- Yan Yu,
- Yan Yu
Affiliations
- Chunjia Zhang
- School of Rehabilitation, Capital Medical University, Beijing, China,
- Chunjia Zhang
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Chunjia Zhang
- China Rehabilitation Science Institute, Beijing, China
- Chunjia Zhang
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Chunjia Zhang
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Zuliyaer Talifu
- School of Rehabilitation, Capital Medical University, Beijing, China,
- Zuliyaer Talifu
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Zuliyaer Talifu
- China Rehabilitation Science Institute, Beijing, China
- Zuliyaer Talifu
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Zuliyaer Talifu
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Zuliyaer Talifu
- School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao, Shandong Province, China
- Xin Xu
- School of Rehabilitation, Capital Medical University, Beijing, China,
- Xin Xu
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Xin Xu
- China Rehabilitation Science Institute, Beijing, China
- Xin Xu
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Xin Xu
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Wubo Liu
- School of Rehabilitation, Capital Medical University, Beijing, China,
- Wubo Liu
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Wubo Liu
- China Rehabilitation Science Institute, Beijing, China
- Wubo Liu
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Wubo Liu
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Wubo Liu
- Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China
- Wubo Liu
- Department of Orthopedics, Qilu Hospital of Shandong University, Jinan, Shandong Province, China
- Han Ke
- School of Rehabilitation, Capital Medical University, Beijing, China,
- Han Ke
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Han Ke
- China Rehabilitation Science Institute, Beijing, China
- Han Ke
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Han Ke
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Han Ke
- Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China
- Han Ke
- Department of Orthopedics, Qilu Hospital of Shandong University, Jinan, Shandong Province, China
- Yunzhu Pan
- School of Rehabilitation, Capital Medical University, Beijing, China,
- Yunzhu Pan
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Yunzhu Pan
- China Rehabilitation Science Institute, Beijing, China
- Yunzhu Pan
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Yunzhu Pan
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Yunzhu Pan
- School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao, Shandong Province, China
- Yan Li
- China Rehabilitation Science Institute, Beijing, China
- Yan Li
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Yan Li
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Fan Bai
- China Rehabilitation Science Institute, Beijing, China
- Fan Bai
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Fan Bai
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Yingli Jing
- China Rehabilitation Science Institute, Beijing, China
- Yingli Jing
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Yingli Jing
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Zihan Li
- China Rehabilitation Science Institute, Beijing, China
- Zihan Li
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Zihan Li
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Zehui Li
- School of Rehabilitation, Capital Medical University, Beijing, China,
- Zehui Li
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Zehui Li
- China Rehabilitation Science Institute, Beijing, China
- Zehui Li
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Zehui Li
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Degang Yang
- School of Rehabilitation, Capital Medical University, Beijing, China,
- Degang Yang
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Degang Yang
- China Rehabilitation Science Institute, Beijing, China
- Degang Yang
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Degang Yang
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Feng Gao
- School of Rehabilitation, Capital Medical University, Beijing, China,
- Feng Gao
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Feng Gao
- China Rehabilitation Science Institute, Beijing, China
- Feng Gao
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Feng Gao
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Liangjie Du
- School of Rehabilitation, Capital Medical University, Beijing, China,
- Liangjie Du
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Liangjie Du
- China Rehabilitation Science Institute, Beijing, China
- Liangjie Du
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Liangjie Du
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Jianjun Li
- School of Rehabilitation, Capital Medical University, Beijing, China,
- Jianjun Li
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Jianjun Li
- China Rehabilitation Science Institute, Beijing, China
- Jianjun Li
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Jianjun Li
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Jianjun Li
- School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao, Shandong Province, China
- Jianjun Li
- Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China
- Yan Yu
- School of Rehabilitation, Capital Medical University, Beijing, China,
- Yan Yu
- China Rehabilitation Science Institute, Beijing, China
- Yan Yu
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Yan Yu
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- DOI
- https://doi.org/10.3389/fnmol.2023.1099256
- Journal volume & issue
-
Vol. 16
Abstract
Spinal cord injury (SCI) is a global medical problem with high disability and mortality rates. At present, the diagnosis and treatment of SCI are still lacking. Spinal cord injury has a complex etiology, lack of diagnostic methods, poor treatment effect and other problems, which lead to the difficulty of spinal cord regeneration and repair, and poor functional recovery. Recent studies have shown that gene expression plays an important role in the regulation of SCI repair. MicroRNAs (miRNAs) are non-coding RNA molecules that target mRNA expression in order to silence, translate, or interfere with protein synthesis. Secondary damage, such as oxidative stress, apoptosis, autophagy, and inflammation, occurs after SCI, and differentially expressed miRNAs contribute to these events. This article reviews the pathophysiological mechanism of miRNAs in secondary injury after SCI, focusing on the mechanism of miRNAs in secondary neuroinflammation after SCI, so as to provide new ideas and basis for the clinical diagnosis and treatment of miRNAs in SCI. The mechanisms of miRNAs in neurological diseases may also make them potential biomarkers and therapeutic targets for spinal cord injuries.
Keywords
- microRNA
- biomarkers
- spinal cord injury
- neuroinflammatory response
- pathophysiological mechanisms
- therapeutic targets
