Frontiers in Medicine (Mar 2023)

Hepatitis B virus and hepatitis D virus infection in women with or at risk for HIV infection in the United States

  • Ilona Argirion,
  • Parag Mahale,
  • Ruth M. Pfeiffer,
  • Ping Liu,
  • Adaora A. Adimora,
  • Matthew J. Akiyama,
  • Matthew J. Akiyama,
  • Hector H. Bolivar,
  • Audrey French,
  • Audrey French,
  • Michael Plankey,
  • Jennifer C. Price,
  • Aadia Rana,
  • Anandi Sheth,
  • Anandi Sheth,
  • Jill Koshiol,
  • Eric C. Seaberg,
  • Mark H. Kuniholm,
  • Jeffrey Glenn,
  • Thomas R. O’Brien

DOI
https://doi.org/10.3389/fmed.2023.1070420
Journal volume & issue
Vol. 10

Abstract

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Hepatitis D virus (HDV) requires co-infection with hepatitis B virus (HBV). Human immunodeficiency virus (HIV) shares transmission routes with these viruses. Among 4,932 US women infected with or at-risk for HIV during 1994–2015, HBV surface antigen (HBsAg) positivity was more common in women with HIV (2.8% vs. 1.2%; p = 0.001); HDV was more common among participants enrolled during 2013–2015 (p = 0.0004) and those with resolved rather than active hepatitis C (1.9% vs. 0.5%; p = 0.02). Among HBsAg-positive women (n = 117), HDV antibody prevalence was 22% and did not vary by HIV status; HDV infection was associated with the presence of advanced fibrosis/cirrhosis at enrollment (adjusted odds ratio, 5.70; 95% confidence interval, 1.46–22.29). Our results demonstrate the importance of HDV testing in HBV-infected US women.

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