Programming effects of maternal stress on the circadian system of adult offspring

Abstract

Circadian rhythms: Maternal stress can disrupt adult offspring’s biological clock When pregnant mothers are stressed, the fetus’s circadian rhythms are reprogrammed, increasing the risk of health complications later in life. Stress during pregnancy was known to negatively affect the fetus, but how it affected circadian rhythms (day/night patterns of alertness) was poorly understood. Kyungjin Kim (Daegu Gyeongbuk Institute of Science and Technology) and Sooyoung Chung (Ewha Womans University, Seoul), both in South Korea, and co-workers stressed pregnant mice by confining them in small tubes, then measured the effects on their offspring. Pups of stressed mothers showed disturbed circadian rhythms, and the effects persisted into adulthood. Further analysis showed that the rhythms were disrupted because individual cells in the key brain region regulating circadian rhythms were poorly synchronized. These results suggest potential treatments to counteract the negative effects of prenatal stress on circadian rhythms.