OXIDATIVE STRESS AS A PATHOGENETIC LINK OF ACUTE ETHANOL POISONING AND ITS CORRECTION WITH CHELATE ZINC COMPOUNDS

S. I. Kolesnikov; A. V. Mashanov; B. Ya. Vlasov; G. G. Yushkov

Acta Biomedica Scientifica (Feb 2012)

OXIDATIVE STRESS AS A PATHOGENETIC LINK OF ACUTE ETHANOL POISONING AND ITS CORRECTION WITH CHELATE ZINC COMPOUNDS

S. I. Kolesnikov,
A. V. Mashanov,
B. Ya. Vlasov,
G. G. Yushkov

Affiliations

S. I. Kolesnikov: Scientific Center of Family Health Problems and Human Reproduction SB RAMS, Irkutsk
A. V. Mashanov: Scientific Research Institute of Biophysics of Angarsk State Technical Academy, Angarsk
B. Ya. Vlasov: Scientific Center of Family Health Problems and Human Reproduction SB RAMS, Irkutsk
G. G. Yushkov: Scientific Research Institute of Biophysics of Angarsk State Technical Academy, Angarsk

Journal volume & issue: Vol. 0, no. 1
pp. 115 – 119

Abstract

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The data on the expressed toxic effect of ethanol in dose DL50 (12 g/kg) on experimental rats were received. The toxic effect was expressed in significant stimulation of processes of lipid peroxidation against the background of antioxidant system suppression. While evaluating the results of statistic analysis it was proved, that new chelate zinc (2,8,9-trihydrozincatrane) in the protective dose of 4 mg/kg under conditions of the acute ethanol poisoning reduces the severity of oxidative stress and normalizes indicators of antioxidant system.

Published in Acta Biomedica Scientifica

ISSN: 2541-9420 (Print); 2587-9596 (Online)
Publisher: Scientific Сentre for Family Health and Human Reproduction Problems
Country of publisher: Russian Federation
LCC subjects: Science
Website: http://actabiomedica.ru/en/

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Abstract

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