Mitochondrial fission promotes self-renewal and tumorigenic potential in prostate cancer

Abstract

The emergence of therapy-resistant cancer stem cells (CSCs) limit the efficacy of prostate cancer treatment. Using genetic knockdown and chemical inhibitors, we demonstrate the critical role of Bromodomain Containing 4 (BRD4) in promoting mitochondrial fission and sustaining CSC expansion. These findings provide a new paradigm for developing novel treatment strategies for prostate cancer.

Keywords

• prostate cancer
• cancer stem cells
• bromodomain and extra-terminal domain proteins
• brd4
• mitochondrial fission
• mff
• epigenetics