International Journal of Molecular Sciences (Jan 2023)

A New Potential Therapeutic Target for Cancer in Ubiquitin-Like Proteins—UBL3

  • Hengsen Zhang,
  • Bin Chen,
  • A. S. M. Waliullah,
  • Shuhei Aramaki,
  • Yashuang Ping,
  • Yusuke Takanashi,
  • Chi Zhang,
  • Qing Zhai,
  • Jing Yan,
  • Soho Oyama,
  • Tomoaki Kahyo,
  • Mitsutoshi Setou

DOI
https://doi.org/10.3390/ijms24021231
Journal volume & issue
Vol. 24, no. 2
p. 1231

Abstract

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Ubiquitin-like proteins (Ubls) are involved in a variety of biological processes through the modification of proteins. Dysregulation of Ubl modifications is associated with various diseases, especially cancer. Ubiquitin-like protein 3 (UBL3), a type of Ubl, was revealed to be a key factor in the process of small extracellular vesicle (sEV) protein sorting and major histocompatibility complex class II ubiquitination. A variety of sEV proteins that affects cancer properties has been found to interact with UBL3. An increasing number of studies has implied that UBL3 expression affects cancer cell growth and cancer prognosis. In this review, we provide an overview of the relationship between various Ubls and cancers. We mainly introduce UBL3 and its functions and summarize the current findings of UBL3 and examine its potential as a therapeutic target in cancers.

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