Testosterone Levels with Insulin Resistance in Type 2 Diabetes Mellitus in Men

Abstract

Objective: To determine the association of testosterone levels with insulin resistance in type 2 diabetes mellitus (T2DM). Study Design: A Cross Sectional Observational Study. Place and Duration of Study: This study was conducted at department of Chemical Pathology Army Medical College Rawalpindi from 11 Nov 2014 to 11 Nov 2015. Materials and Methods: The study included 110 male participants. Two groups were made. Group A, included 55 patients of T2DM selected randomly from Endocrinology Department of Military Hospital Rawalpindi. Group B included healthy controls. Each group was further categorized on the basis of age and decade wise sub groups were made. Fasting plasma glucose (FPG), serum testosterone levels, serum sex hormone binding globulin levels (SHBG), glycosylated hemoglobin and fasting insulin levels were checked using fasting blood samples. The insulin resistance was calculated using Homeostatic Model for Assessment of Insulin Resistance (HOMA‐IR). Data obtained was analyzed by SPSS version 20. Results: Mean serum testosterone levels in group A (n=55) 9.36±5.06nmol/L was significantly lower (P 0.0001) as compared to group B (n=55) 15.10±6.99nmol/L. Fasting plasma glucose (11.50±3.35 vs. 4.23±0.63nmol/L), HbA1c (6.86±0.35 vs. 5.05±0.45%), serum insulin (10.61±4.87 vs. 5.71±2.43μIU/ml) and insulin resistance calculated by HOMA‐IR (5.51±3.73 vs. 1.07±0.45) were significantly higher in group A as compared to group B. Conclusion: The present study shows that a lower levels of serum testosterone are found in diabetic patients. Moreover there is significant negative correlation of serum testosterone with insulin resistance.

Keywords

• type 2 diabetes mellitus, testosterone, insulin resistance, homeostatic model assessment‐insulin resistance.