Liver Receptor homolog-1 Regulates Apoptosis of Bovine Ovarian Granulosa Cells by Progestogen Receptor Signaling Pathway

Dejun Xu; Xiaohan Jiang; Yukun Wang; Shuaifei Song

doi:10.3390/ani12091213

Animals (May 2022)

Liver Receptor homolog-1 Regulates Apoptosis of Bovine Ovarian Granulosa Cells by Progestogen Receptor Signaling Pathway

Dejun Xu,
Xiaohan Jiang,
Yukun Wang,
Shuaifei Song

Affiliations

Dejun Xu: Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China
Xiaohan Jiang: College of Animal Science and Technology, Northwest A&F University, No. 3 Taicheng Road, Xianyang 712100, China
Yukun Wang: Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China
Shuaifei Song: Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China

DOI: https://doi.org/10.3390/ani12091213
Journal volume & issue: Vol. 12, no. 9
p. 1213

Abstract

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The purpose of the present investigation was to assess the function of LRH-1 on GCs and the mechanisms involved. Here, LRH- was highly expressed in the bovine GCs of atretic follicles. Treatment with 50 μM of LRH-1 agonist (DLPC) significantly induced the expression of LRH-1 (p p p p < 0.05). Taken together, these results demonstrate that LRH-1 might be dependent on the progestogen receptor signaling pathway to modulate bovine follicular atresia.

Published in Animals

ISSN: 2076-2615 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Agriculture: Animal culture: Veterinary medicine; Science: Zoology
Website: http://www.mdpi.com/journal/animals/

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