Treatment strategy for HPV-positive oropharyngeal cancer: a literature review

Abstract

This review presents data on the strategy for the treatment of oropharyngeal cancer associated with human papillomavirus. This pathology occurs mainly in young people without bad habits. Despite the low degree of differentiation, the course of the disease is relatively favorable. In addition, the tumor has a rather high sensitivity to conservative methods of treatment. The article discusses various options for de-escalation of therapy, modern drug regimens, as well as the results of the most significant randomized trials on this issue.

Keywords

• рак ротоглотки
• ассоциированный с вирусом папилломы человека
• р16-положительный орофарингеальный рак
• плоскоклеточный рак
• деэскалация лечения
• химиолучевое лечение