Sporadic Creutzfeldt-Jakob disease: clinical observation

Abstract

Creutzfeldt-Jakob disease (CJD) is a form of human prion diseases,fatal neurodegenerative conditions. They can be etiologicallydivided into sporadic, hereditary and acquired forms.Conformational change of the normal (cellular) form of prionprotein (PrPc) to a pathological form (PrPSс) is a central event inthe formation of an infectious agent. In this article, diagnosticcriteria for sporadic CJD are summarized. Case report of probablesporadic CJD is presented. Many therapeutic strategies(based on cell cultures or animals) have been tested as potentialtreatments for prion diseases. However, only few clinical trialsare in progress now or have been completed.

Keywords

• sporadic creutzfeldt-jakob disease
• diagnostic criteria
• prion