Nature Communications (Nov 2018)
Human milk oligosaccharides, milk microbiome and infant gut microbiome modulate neonatal rotavirus infection
- Sasirekha Ramani,
- Christopher J. Stewart,
- Daniel R. Laucirica,
- Nadim J. Ajami,
- Bianca Robertson,
- Chloe A. Autran,
- Dhairyasheel Shinge,
- Sandya Rani,
- Sasirekha Anandan,
- Liya Hu,
- Josephine C. Ferreon,
- Kurien A. Kuruvilla,
- Joseph F. Petrosino,
- B. V. Venkataram Prasad,
- Lars Bode,
- Gagandeep Kang,
- Mary K. Estes
Affiliations
- Sasirekha Ramani
- Department of Molecular Virology and Microbiology, Baylor College of Medicine
- Christopher J. Stewart
- Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine
- Daniel R. Laucirica
- Department of Molecular Virology and Microbiology, Baylor College of Medicine
- Nadim J. Ajami
- Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine
- Bianca Robertson
- Department of Pediatrics and Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence, University of California, San Diego
- Chloe A. Autran
- Department of Pediatrics and Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence, University of California, San Diego
- Dhairyasheel Shinge
- Division of Gastrointestinal Sciences, Christian Medical College
- Sandya Rani
- Division of Gastrointestinal Sciences, Christian Medical College
- Sasirekha Anandan
- Division of Gastrointestinal Sciences, Christian Medical College
- Liya Hu
- Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine
- Josephine C. Ferreon
- Department of Pharmacology and Chemical Biology, Baylor College of Medicine
- Kurien A. Kuruvilla
- Department of Neonatology, Christian Medical College
- Joseph F. Petrosino
- Department of Molecular Virology and Microbiology, Baylor College of Medicine
- B. V. Venkataram Prasad
- Department of Molecular Virology and Microbiology, Baylor College of Medicine
- Lars Bode
- Department of Pediatrics and Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence, University of California, San Diego
- Gagandeep Kang
- Division of Gastrointestinal Sciences, Christian Medical College
- Mary K. Estes
- Department of Molecular Virology and Microbiology, Baylor College of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-07476-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Neonatal rotavirus infections are associated with gastrointestinal symptoms in some settings, but the role of host factors in clinical presentation is unclear. Here, Ramani et al. show that human milk oligosaccharides and microbiome are associated with symptomatic infection with neonatal strain G10P[11].
