Post-surgical antibiotic prophylaxis: Impact of pharmacist’s educational intervention on appropriate use of antibiotics

Abstract

Background: Guidelines assisted appropriate use of prophylactic antibiotics can lower the prevalence of surgical site infections (SSIs). The present study was conducted to evaluate the impact and cost-benefit value of pharmacist’s educational intervention for antibiotic use in post-surgical prophylaxis. Methods: A prospective quasi experimental study was conducted by enrolling 450 patients from tertiary care hospital of Lahore, Pakistan, 225 patients in each, control and intervention, arm using non-random convenient sampling. The study parameters included antibiotic indication, choice, dose, frequency, duration and associated costs. This study is registered with Chinese Clinical Trial Registry # ChiCTR-OON-17013246. Results and conclusion: After educational intervention, in post-intervention arm, total compliance in terms of correct antibiotic choice, dose, frequency and duration increased from 1.3% to 12.4%. The rate of inappropriate antibiotic choice did not change significantly. After intervention only metronidazole utilization decreased (16%) significantly (p = 0.011). Significant reductions were observed in mean duration of antibiotic prophylaxis (17%, p = 0.003), average number of prescribed antibiotics (9.1%, p = 0.014) and average antibiotic cost (25.7%, p = 0.03), with reduction in mean hospitalization cost (p = 0.003) and length of stay (p = 0.023). Educational intervention was significantly associated (OR; 2.4, p = 0.005) with appropriate antibiotic prophylaxis. The benefit of pharmacist intervention, mean antibiotic cost savings to mean cost of pharmacist time, was 4.8:1. Thus, the educational intervention resulted in significant reductions in the duration and average number of antibiotic use having considerable effect on therapy and hospitalization cost. Keywords: Surgery, Pharmacist interventions, Antibiotics, Rational use, Prophylaxis, Cost analysis