Nature Communications (May 2020)
Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma
- Xing Hua,
- Wei Zhao,
- Angela C. Pesatori,
- Dario Consonni,
- Neil E. Caporaso,
- Tongwu Zhang,
- Bin Zhu,
- Mingyi Wang,
- Kristine Jones,
- Belynda Hicks,
- Lei Song,
- Joshua Sampson,
- David C. Wedge,
- Jianxin Shi,
- Maria Teresa Landi
Affiliations
- Xing Hua
- Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Wei Zhao
- Integrative Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Angela C. Pesatori
- Department of Clinical Sciences and Community Health, University of Milan
- Dario Consonni
- Fondazione IRCCS Ca’ Granda—Ospedale Maggiore Policlinico, Occupational Health Unit
- Neil E. Caporaso
- Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Tongwu Zhang
- Integrative Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Bin Zhu
- Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Mingyi Wang
- Cancer Genome Research Laboratory, Leidos Biomedical Research Inc.
- Kristine Jones
- Cancer Genome Research Laboratory, Leidos Biomedical Research Inc.
- Belynda Hicks
- Cancer Genome Research Laboratory, Leidos Biomedical Research Inc.
- Lei Song
- Cancer Genome Research Laboratory, Leidos Biomedical Research Inc.
- Joshua Sampson
- Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- David C. Wedge
- Big Data Institute
- Jianxin Shi
- Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Maria Teresa Landi
- Integrative Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- DOI
- https://doi.org/10.1038/s41467-020-16295-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
Many tumors are known to be heterogeneous. Here, the authors examined multiple samples from 84 patients with lung adenocarcinoma and demonstrate that the intratumor heterogeneity of methylation and copy number associates with poor prognosis.
