PLoS ONE (Jan 2022)

Predictors and outcomes of peritoneal dialysis-related infections due to filamentous molds (MycoPDICS)

  • Talerngsak Kanjanabuch,
  • Tanawin Nopsopon,
  • Tanittha Chatsuwan,
  • Sirirat Purisinsith,
  • David W Johnson,
  • Nibondh Udomsantisuk,
  • Guttiga Halue,
  • Pichet Lorvinitnun,
  • Pongpratch Puapatanakul,
  • Krit Pongpirul,
  • Ussanee Poonvivatchaikarn,
  • Sajja Tatiyanupanwong,
  • Saowalak Chowpontong,
  • Rutchanee Chieochanthanakij,
  • Oranan Thamvichitkul,
  • Worapot Treamtrakanpon,
  • Wadsamon Saikong,
  • Uraiwan Parinyasiri,
  • Piyatida Chuengsaman,
  • Phongsak Dandecha,
  • Jeffrey Perl,
  • Kriang Tungsanga,
  • Somchai Eiam-Ong,
  • Suchai Sritippayawan,
  • Surasak Kantachuvesiri,
  • on behalf of The Advisory Board of Peritoneal Dialysis, Nephrology Society of Thailand

Journal volume & issue
Vol. 17, no. 5

Abstract

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Introduction We sought to evaluate the predictors and outcomes of mold peritonitis in patients with peritoneal dialysis (PD). Methods This cohort study included PD patients from the MycoPDICS database who had fungal peritonitis between July 2015-June 2020. Patient outcomes were analyzed by Kaplan Meier curves and the Log-rank test. Multivariable Cox proportional hazards model regression was used to estimating associations between fungal types and patients’ outcomes. Results The study included 304 fungal peritonitis episodes (yeasts n = 129, hyaline molds n = 122, non-hyaline molds n = 44, and mixed fungi n = 9) in 303 patients. Fungal infections were common during the wet season (p Conclusion Non-hyaline-mold peritonitis had worse survival. Longer duration and higher daily dosage of antifungal treatment were associated with better survival. Deviations from the 2016 ISPD Peritonitis Guideline recommendations concerning treatment duration and catheter removal timing were independently associated with higher mortality.