Frontiers in Cell and Developmental Biology (Dec 2020)

Deform-nu: A DNA Deformation Energy-Based Predictor for Nucleosome Positioning

  • Guoqing Liu,
  • Hongyu Zhao,
  • Hu Meng,
  • Yongqiang Xing,
  • Hui Yang,
  • Hao Lin

DOI
https://doi.org/10.3389/fcell.2020.596341
Journal volume & issue
Vol. 8

Abstract

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The structure and function of chromatin can be regulated through positioning patterns of nucleosomes. DNA-based processes are regulated via nucleosomes. Therefore, it is significant to determine nucleosome positions in DNA-based processes. A deformation energy model was proposed to predict nucleosome positions in our previous study. A free web server based on the model (http://lin-group.cn/server/deform-nu/) was firstly established to estimate the occupancy and rotational positioning of nucleosomes in the study. Then, the performance of the model was verified by several examples. The results indicated that nucleosome positioning relied on the physical properties of DNA, such as deformation energy.

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