Molecular Cancer (Dec 2023)

Effects of RNA methylation on Tumor angiogenesis and cancer progression

  • Mingyu Han,
  • Haifeng Sun,
  • Quanbo Zhou,
  • Jinbo Liu,
  • Junhong Hu,
  • Weitang Yuan,
  • Zhenqiang Sun

DOI
https://doi.org/10.1186/s12943-023-01879-8
Journal volume & issue
Vol. 22, no. 1
pp. 1 – 14

Abstract

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Abstract Tumor angiogenesis plays vital roles in the growth and metastasis of cancer. RNA methylation is one of the most common modifications and is widely observed in eukaryotes and prokaryotes. Accumulating studies have revealed that RNA methylation affects the occurrence and development of various tumors. In recent years, RNA methylation has been shown to play an important role in regulating tumor angiogenesis. In this review, we mainly elucidate the mechanisms and functions of RNA methylation on angiogenesis and progression in several cancers. We then shed light on the role of RNA methylation-associated factors and pathways in tumor angiogenesis. Finally, we describe the role of RNA methylation as potential biomarker and novel therapeutic target.

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