Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement

Lawrence S. Hsieh; John H. Wen; Kumiko Claycomb; Yuegao Huang; Felicia A. Harrsch; Janice R. Naegele; Fahmeed Hyder; Gordon F. Buchanan; Angelique Bordey

doi:10.1038/ncomms11753

Nature Communications (Jun 2016)

Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement

Lawrence S. Hsieh,
John H. Wen,
Kumiko Claycomb,
Yuegao Huang,
Felicia A. Harrsch,
Janice R. Naegele,
Fahmeed Hyder,
Gordon F. Buchanan,
Angelique Bordey

Affiliations

Lawrence S. Hsieh: Departments of Neurosurgery, and Cellular and Molecular Physiology, Yale University School of Medicine
John H. Wen: Departments of Neurosurgery, and Cellular and Molecular Physiology, Yale University School of Medicine
Kumiko Claycomb: Department of Neurology, Yale University School of Medicine
Yuegao Huang: Magnetic Resonance Research Center, Yale University School of Medicine
Felicia A. Harrsch: Department of Biology, Wesleyan University
Janice R. Naegele: Department of Biology, Wesleyan University
Fahmeed Hyder: Magnetic Resonance Research Center, Yale University School of Medicine
Gordon F. Buchanan: Department of Neurology, Yale University School of Medicine
Angelique Bordey: Departments of Neurosurgery, and Cellular and Molecular Physiology, Yale University School of Medicine

DOI: https://doi.org/10.1038/ncomms11753
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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The etiology of focal cortical dysplasia (FCD) is not fully understood. Here authors generate an mTORC1 overactivation mouse model that recapitulates hallmarks of type II FCDs, including spontaneous seizures, and suggest that neuronal defects, rather than macrostructural changes, lead to seizures.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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