The anti-viral dynamin family member MxB participates in mitochondrial integrity

Hong Cao; E. W. Krueger; Jing Chen; Kristina Drizyte-Miller; Mary E. Schulz; Mark A. McNiven

doi:10.1038/s41467-020-14727-w

Nature Communications (Feb 2020)

The anti-viral dynamin family member MxB participates in mitochondrial integrity

Hong Cao,
E. W. Krueger,
Jing Chen,
Kristina Drizyte-Miller,
Mary E. Schulz,
Mark A. McNiven

Affiliations

Hong Cao: Department of Biochemistry and Molecular Biology, Mayo Clinic
E. W. Krueger: Center for Basic Research in Digestive Diseases, Division of Gastroenterology & Hepatology, Mayo Clinic
Jing Chen: Center for Basic Research in Digestive Diseases, Division of Gastroenterology & Hepatology, Mayo Clinic
Kristina Drizyte-Miller: Biochemistry and Molecular Biology Program, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic
Mary E. Schulz: Center for Basic Research in Digestive Diseases, Division of Gastroenterology & Hepatology, Mayo Clinic
Mark A. McNiven: Department of Biochemistry and Molecular Biology, Mayo Clinic

DOI: https://doi.org/10.1038/s41467-020-14727-w
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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Mx proteins belong to the dynamin family of large GTPases and are highly induced by interferon in virally infected cells. The authors show that uninfected immune cells and hepatocytes also express MxB protein that associates with mitochondria to alter the morphology and genome of this organelle.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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