Optical-Spectrometry-Based Method for Immunosuppressant Medicine Level Detection in Aqueous Solutions

Marcin Marzejon; Monika Kosowska; Daria Majchrowicz; Barbara Bułło-Piontecka; Michał Wąsowicz; Małgorzata Jędrzejewska-Szczerska

doi:10.3390/s18072001

Sensors (Jun 2018)

Optical-Spectrometry-Based Method for Immunosuppressant Medicine Level Detection in Aqueous Solutions

Marcin Marzejon,
Monika Kosowska,
Daria Majchrowicz,
Barbara Bułło-Piontecka,
Michał Wąsowicz,
Małgorzata Jędrzejewska-Szczerska

Affiliations

Marcin Marzejon: Department of Metrology and Optoelectronics, Faculty of Electronics, Telecommunications and Informatics, Gdańsk University of Technology, 11/12 Narutowicza Street, 80-233 Gdansk, Poland
Monika Kosowska: Department of Metrology and Optoelectronics, Faculty of Electronics, Telecommunications and Informatics, Gdańsk University of Technology, 11/12 Narutowicza Street, 80-233 Gdansk, Poland
Daria Majchrowicz: Department of Metrology and Optoelectronics, Faculty of Electronics, Telecommunications and Informatics, Gdańsk University of Technology, 11/12 Narutowicza Street, 80-233 Gdansk, Poland
Barbara Bułło-Piontecka: Department of Nephrology, Transplantology and Internal Diseases, Faculty of Medicine, Medical University of Gdańsk, 3a Marii Skłodowskiej-Curie Street, 80-210 Gdansk, Poland
Michał Wąsowicz: Department of Morphological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, 159 Nowoursynowska Street, 02-776 Warszawa, Poland
Małgorzata Jędrzejewska-Szczerska: Department of Metrology and Optoelectronics, Faculty of Electronics, Telecommunications and Informatics, Gdańsk University of Technology, 11/12 Narutowicza Street, 80-233 Gdansk, Poland

DOI: https://doi.org/10.3390/s18072001
Journal volume & issue: Vol. 18, no. 7
p. 2001

Abstract

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In this paper, an investigation into detecting immunosuppressive medicine in aqueous solutions using a spectrometry-based technique is described. Using optical transmissive spectrometry, absorbance measurements in the spectra range from 250 nm to 1000 nm were carried out for different cyclosporine A (CsA) concentrations in aqueous solutions. The experiment was conducted for samples both with and without interferent substances—glucose and sodium chloride. Using a dedicated algorithm, the measured data was analyzed and a high correlation coefficient R2 = 0.8647 was achieved. The experiment showed that the described technique allowed for the detection of various CsA concentration levels in a selective, label-free and simple way. This method could be used in medicine, veterinary medicine and laboratory diagnostics.

Published in Sensors

ISSN: 1424-8220 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Chemical technology
Website: http://www.mdpi.com/journal/sensors

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