Revista Brasileira de Ginecologia e Obstetrícia (Nov 2017)

Sirtuin 1 Levels in Recurrent Implantation Failure

  • Yaprak Engin-Ustun,
  • A. Seval Ozgu-Erdinc,
  • Emel Kiyak Caglayan,
  • Cavidan Gulerman,
  • Esma Sarikaya,
  • Ayla Aktulay,
  • Canan Demirtas,
  • Salim Erkaya,
  • Nafiye Yilmaz

DOI
https://doi.org/10.1055/s-0037-1606349
Journal volume & issue
Vol. 39, no. 10
pp. 541 – 544

Abstract

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Abstract Sirtuin 1 has an important role in cellular processes, including apoptosis and cellular stress. The purpose of this study was to assess serum sirtuin 1 levels in women with recurrent implantation failure (RIF). In this cross-sectional study, we included 28 women with RIF, 29 healthy women who had conceived by in vitro fertilization (IVF), and 30 women with a 1-cycle failure of IVF as controls. Human serum nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin-1 (SIRT1/SIRT2L1) levels were detected using a commercial colorimetric kit. Recurrent implantation failure patients have higher sirtuin 1 levels than non-pregnant women and healthy pregnant women, but this difference did not reach statistical significance due to the low number of patients in our study. These higher sirtuin 1 levels may result from the inflammation imbalance of RIF patients. The only statistically significant correlation found was between age and sirtuin (r = 0.277, p = 0.009).

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