Nature Communications (Apr 2018)
TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis
- Chunmei Wang,
- Yanlin He,
- Pingwen Xu,
- Yongjie Yang,
- Kenji Saito,
- Yan Xia,
- Xiaofeng Yan,
- Antentor Hinton Jr,
- Chunling Yan,
- Hongfang Ding,
- Likai Yu,
- Gang Shu,
- Rajat Gupta,
- Qi Wu,
- Qingchun Tong,
- William R. Lagor,
- Elsa R. Flores,
- Yong Xu
Affiliations
- Chunmei Wang
- Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine
- Yanlin He
- Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine
- Pingwen Xu
- Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine
- Yongjie Yang
- Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine
- Kenji Saito
- Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine
- Yan Xia
- Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine
- Xiaofeng Yan
- Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine
- Antentor Hinton Jr
- Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine
- Chunling Yan
- Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine
- Hongfang Ding
- Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine
- Likai Yu
- Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine
- Gang Shu
- Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine
- Rajat Gupta
- Molecular Physiology and Biophysics, Baylor College of Medicine
- Qi Wu
- Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine
- Qingchun Tong
- Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston
- William R. Lagor
- Molecular Physiology and Biophysics, Baylor College of Medicine
- Elsa R. Flores
- Department of Molecular Oncology, Cancer Biology and Evolution Program, Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center
- Yong Xu
- Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-03796-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Sexual dimorphism exists in a number of physiological processes, including energy homeostasis. Here, the authors show that pro-opiomelanocortin neurons in female mice fire more rapidly than males, and that deletion of the transcription TAp63 leads to a reduced neuronal firing rate and a male-like susceptibility to diet-induced obesity.
