Gerontology and Geriatric Medicine (Nov 2023)

Aging is Associated With Constipation in Japanese Patients With Ulcerative Colitis: A Post Hoc Analysis

  • Sen Yagi MD, PhD,
  • Shinya Furukawa MD, PhD,
  • Teruki Miyake MD, PhD,
  • Osamu Yoshida MD, PhD,
  • Kana Shiraishi MD,
  • Kazuhiro Tange MD PhD,
  • Yu Hashimoto MD, PhD,
  • Shogo Kitahata MD, PhD,
  • Tomoyuki Ninomiya MD, PhD,
  • Masakazu Hanayama MD, PhD,
  • Seiyuu Suzuki MD, PhD,
  • Naozumi Shibata MD, PhD,
  • Hidehiro Murakami MD, PhD,
  • Katsuhisa Ohashi MD, PhD,
  • Hideomi Tomida MD, PhD,
  • Yasunori Yamamoto MD, PhD,
  • Eiji Takeshita MD, PhD,
  • Yoshio Ikeda MD, PhD,
  • Yoichi Hiasa MD, PhD

DOI
https://doi.org/10.1177/23337214231215637
Journal volume & issue
Vol. 9

Abstract

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Aim: Age is a risk factor for constipation. Constipation is common in patients with ulcerative colitis (UC) and has been positively associated with disease activity, but evidence is limited. This study aimed to assess the association between disease activity and constipation in patients with UC. Methods : The study subjects consisted of 290 Japanese UC patients. The definition of constipation was based on Rome I criteria and/or medication for constipation. Information on and lifestyle habits was obtained from a self-administered questionnaire. Mucosal healing (MH) was defined as Mayo endoscopic subscore 0. Clinical remission (CR) was defined as both the absence of rectal bleeding and no abnormally high stool frequency (70 years was 10.0%, 5.8%, 15.7%, 11.8%, and 25.6%, respectively. >70 years was independently and positively associated with the prevalence of constipation (adjusted odds ratio 3.64 [95% confidence interval 1.26, 10.95], p for trend: .001). Conclusions: Aging was independently and positively associated with the prevalence of constipation in UC.