Communications Biology (Mar 2022)

Agonistic CD27 antibody potency is determined by epitope-dependent receptor clustering augmented through Fc-engineering

  • Franziska Heckel,
  • Anna H. Turaj,
  • Hayden Fisher,
  • H. T. Claude Chan,
  • Michael J. E. Marshall,
  • Osman Dadas,
  • Christine A. Penfold,
  • Tatyana Inzhelevskaya,
  • C. Ian Mockridge,
  • Diego Alvarado,
  • Ivo Tews,
  • Tibor Keler,
  • Stephen A. Beers,
  • Mark S. Cragg,
  • Sean H. Lim

DOI
https://doi.org/10.1038/s42003-022-03182-6
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 15

Abstract

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Agonistic CD27 monoclonal antibodies can be used to enhance the efficacy of depleting antibodies such as anti-CTLA-4 in a colon adenocarcinoma tumour model. CD27 antibody agonism is dependent on isotype and epitope specificity.