Multiple myeloma immunoglobulin lambda translocations portend poor prognosis

Benjamin G. Barwick; Paola Neri; Nizar J. Bahlis; Ajay K. Nooka; Madhav V. Dhodapkar; David L. Jaye; Craig C. Hofmeister; Jonathan L. Kaufman; Vikas A. Gupta; Daniel Auclair; Jonathan J. Keats; Sagar Lonial; Paula M. Vertino; Lawrence H. Boise

doi:10.1038/s41467-019-09555-6

Nature Communications (Apr 2019)

Multiple myeloma immunoglobulin lambda translocations portend poor prognosis

Benjamin G. Barwick,
Paola Neri,
Nizar J. Bahlis,
Ajay K. Nooka,
Madhav V. Dhodapkar,
David L. Jaye,
Craig C. Hofmeister,
Jonathan L. Kaufman,
Vikas A. Gupta,
Daniel Auclair,
Jonathan J. Keats,
Sagar Lonial,
Paula M. Vertino,
Lawrence H. Boise

Affiliations

Benjamin G. Barwick: Department of Hematology and Medical Oncology, Emory University School of Medicine
Paola Neri: Charbonneau Cancer Research Institute, University of Calgary
Nizar J. Bahlis: Charbonneau Cancer Research Institute, University of Calgary
Ajay K. Nooka: Department of Hematology and Medical Oncology, Emory University School of Medicine
Madhav V. Dhodapkar: Department of Hematology and Medical Oncology, Emory University School of Medicine
David L. Jaye: Winship Cancer Institute, Emory University
Craig C. Hofmeister: Department of Hematology and Medical Oncology, Emory University School of Medicine
Jonathan L. Kaufman: Department of Hematology and Medical Oncology, Emory University School of Medicine
Vikas A. Gupta: Department of Hematology and Medical Oncology, Emory University School of Medicine
Daniel Auclair: Multiple Myeloma Research Foundation
Jonathan J. Keats: Translational Genomics Research Institute
Sagar Lonial: Department of Hematology and Medical Oncology, Emory University School of Medicine
Paula M. Vertino: Department of Radiation Oncology, Emory University School of Medicine
Lawrence H. Boise: Department of Hematology and Medical Oncology, Emory University School of Medicine

DOI: https://doi.org/10.1038/s41467-019-09555-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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Multiple myeloma is frequently characterised by translocation of genes next to the immunoglobulin heavy chain locus. In this study, the authors sequence a large cohort of high risk myeloma samples and find translocations of cMyc to the immunoglobulin heavy chain locus and this is associated with poor prognosis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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