NLRP6 is required for cancer-derived exosome-modified macrophage M2 polarization and promotes metastasis in small cell lung cancer

Xinrui Rao; Xiaoshu Zhou; Geng Wang; Xiaohua Jie; Biyuan Xing; Yingzhuo Xu; Yunshang Chen; Jun Li; Kuikui Zhu; Zilong Wu; Gang Wu; Chuangyan Wu; Rui Zhou

doi:10.1038/s41419-022-05336-0

Cell Death and Disease (Oct 2022)

NLRP6 is required for cancer-derived exosome-modified macrophage M2 polarization and promotes metastasis in small cell lung cancer

Xinrui Rao,
Xiaoshu Zhou,
Geng Wang,
Xiaohua Jie,
Biyuan Xing,
Yingzhuo Xu,
Yunshang Chen,
Jun Li,
Kuikui Zhu,
Zilong Wu,
Gang Wu,
Chuangyan Wu,
Rui Zhou

Affiliations

Xinrui Rao: Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Xiaoshu Zhou: Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Geng Wang: Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Xiaohua Jie: Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Biyuan Xing: Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Yingzhuo Xu: Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Yunshang Chen: Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Jun Li: Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Kuikui Zhu: Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Zilong Wu: Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Gang Wu: Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Chuangyan Wu: Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Rui Zhou: Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

DOI: https://doi.org/10.1038/s41419-022-05336-0
Journal volume & issue: Vol. 13, no. 10
pp. 1 – 12

Abstract

Read online

A schematic illustration showing that SCLC-derived exosomes polarize M2 macrophages to promote SCLC metastasis through the NLRP6/NF-κB pathway.

Published in Cell Death and Disease

ISSN: 2041-4889 (Online)
Publisher: Nature Publishing Group
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General): Cytology
Website: http://www.nature.com/cddis/index.html

About the journal