A Slam-dependent hemophore contributes to heme acquisition in the bacterial pathogen Acinetobacter baumannii

Thomas J. Bateman; Megha Shah; Timothy Pham Ho; Hyejin Esther Shin; Chuxi Pan; Greg Harris; Jamie E. Fegan; Epshita A. Islam; Sang Kyun Ahn; Yogesh Hooda; Scott D. Gray-Owen; Wangxue Chen; Trevor F. Moraes

doi:10.1038/s41467-021-26545-9

Nature Communications (Nov 2021)

A Slam-dependent hemophore contributes to heme acquisition in the bacterial pathogen Acinetobacter baumannii

Thomas J. Bateman,
Megha Shah,
Timothy Pham Ho,
Hyejin Esther Shin,
Chuxi Pan,
Greg Harris,
Jamie E. Fegan,
Epshita A. Islam,
Sang Kyun Ahn,
Yogesh Hooda,
Scott D. Gray-Owen,
Wangxue Chen,
Trevor F. Moraes

Affiliations

Thomas J. Bateman: Department of Biochemistry, University of Toronto
Megha Shah: Department of Biochemistry, University of Toronto
Timothy Pham Ho: Department of Biochemistry, University of Toronto
Hyejin Esther Shin: Department of Biochemistry, University of Toronto
Chuxi Pan: Department of Biochemistry, University of Toronto
Greg Harris: National Research Council Canada, Human Health Therapeutics (HHT) Research Center
Jamie E. Fegan: Department of Molecular Genetics, University of Toronto
Epshita A. Islam: Department of Biochemistry, University of Toronto
Sang Kyun Ahn: Department of Molecular Genetics, University of Toronto
Yogesh Hooda: Department of Biochemistry, University of Toronto
Scott D. Gray-Owen: Department of Molecular Genetics, University of Toronto
Wangxue Chen: National Research Council Canada, Human Health Therapeutics (HHT) Research Center
Trevor F. Moraes: Department of Biochemistry, University of Toronto

DOI: https://doi.org/10.1038/s41467-021-26545-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

Read online

Nutrient acquisition is crucial for the growth of pathogens within their hosts. Here, Bateman et al. identify a set of proteins required for heme uptake from host hemoglobin and serum albumin in the pathogen Acinetobacter baumannii.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal