Nature Communications (Jul 2021)

Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis

  • Yoshiaki Ito,
  • Tokio Matsuzaki,
  • Fumiaki Ayabe,
  • Sho Mokuda,
  • Ryota Kurimoto,
  • Takahide Matsushima,
  • Yusuke Tabata,
  • Maiko Inotsume,
  • Hiroki Tsutsumi,
  • Lin Liu,
  • Masahiro Shinohara,
  • Yoko Tanaka,
  • Ryo Nakamichi,
  • Keiichiro Nishida,
  • Martin K. Lotz,
  • Hiroshi Asahara

DOI
https://doi.org/10.1038/s41467-021-24460-7
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

Read online

Osteoarthritis is caused by an imbalance between extracellular matrix synthesis and degradation. Here, the authors show that both strands of microRNA-455, -5p and -3p, target HIF2α and regulate cartilage homeostasis, and show that overexpression of these miRNAs is protective against osteoarthritis in mice.