PLoS ONE (Jan 2022)

Appetite loss at discharge from acute decompensated heart failure: Observation from KCHF registry.

  • Erika Yamamoto,
  • Takao Kato,
  • Hidenori Yaku,
  • Takeshi Morimoto,
  • Yasutaka Inuzuka,
  • Yodo Tamaki,
  • Neiko Ozasa,
  • Yusuke Yoshikawa,
  • Takeshi Kitai,
  • Ryoji Taniguchi,
  • Moritake Iguchi,
  • Masashi Kato,
  • Mamoru Takahashi,
  • Toshikazu Jinnai,
  • Tomoyuki Ikeda,
  • Kazuya Nagao,
  • Takafumi Kawai,
  • Akihiro Komasa,
  • Ryusuke Nishikawa,
  • Yuichi Kawase,
  • Takashi Morinaga,
  • Mitsunori Kawato,
  • Yuta Seko,
  • Masayuki Shiba,
  • Mamoru Toyofuku,
  • Yutaka Furukawa,
  • Yoshihisa Nakagawa,
  • Kenji Ando,
  • Kazushige Kadota,
  • Satoshi Shizuta,
  • Koh Ono,
  • Yukihito Sato,
  • Koichiro Kuwahara,
  • Takeshi Kimura

DOI
https://doi.org/10.1371/journal.pone.0267327
Journal volume & issue
Vol. 17, no. 5
p. e0267327

Abstract

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ObjectiveThe complex link between nutritional status, protein and lipid synthesis, and immunity plays an important prognostic role in patients with heart failure. However, the association between appetite loss at discharge and long-term outcome remains unclear.MethodsThe Kyoto Congestive Heart Failure registry is a prospective cohort study that enrolled consecutive patients hospitalized for acute decompensated heart failure (ADHF) in Japan. We assessed 3528 patients alive at discharge, and for whom appetite and follow-up data were available. We compared one-year clinical outcomes in patients with and without appetite loss at discharge.ResultsIn the multivariable logistic regression analysis using 19 clinical and laboratory factors with P value 1.0mg/dL (OR: 1.49, 95%CI: 1.04-2.14, P = 0.03), and presence of edema at discharge (OR: 4.30, 95%CI: 2.99-6.22, PConclusionsLoss of appetite at discharge was associated with worse 1-year mortality in patients with ADHF. Appetite is a simple, reliable, and useful subjective marker for risk stratification of patients with ADHF.