Graphene Oxide Hybridized nHAC/PLGA Scaffolds Facilitate the Proliferation of MC3T3-E1 Cells

Chunyong Liang; Yongchao Luo; Guodong Yang; Dan Xia; Lei Liu; Xiaomin Zhang; Hongshui Wang

doi:10.1186/s11671-018-2432-6

Nanoscale Research Letters (Jan 2018)

Graphene Oxide Hybridized nHAC/PLGA Scaffolds Facilitate the Proliferation of MC3T3-E1 Cells

Chunyong Liang,
Yongchao Luo,
Guodong Yang,
Dan Xia,
Lei Liu,
Xiaomin Zhang,
Hongshui Wang

Affiliations

Chunyong Liang: Research Institute for Energy Equipment Materials, Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, College of Materials Science and Engineering, Hebei University of Technology
Yongchao Luo: Research Institute for Energy Equipment Materials, Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, College of Materials Science and Engineering, Hebei University of Technology
Guodong Yang: Institute for Advanced Materials, Jiangsu University
Dan Xia: Research Institute for Energy Equipment Materials, Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, College of Materials Science and Engineering, Hebei University of Technology
Lei Liu: Institute for Advanced Materials, Jiangsu University
Xiaomin Zhang: Research Institute for Energy Equipment Materials, Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, College of Materials Science and Engineering, Hebei University of Technology
Hongshui Wang: Research Institute for Energy Equipment Materials, Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, College of Materials Science and Engineering, Hebei University of Technology

DOI: https://doi.org/10.1186/s11671-018-2432-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

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Abstract Biodegradable porous biomaterial scaffolds play a critical role in bone regeneration. In this study, the porous nano-hydroxyapatite/collagen/poly(lactic-co-glycolic acid)/graphene oxide (nHAC/PLGA/GO) composite scaffolds containing different amount of GO were fabricated by freeze-drying method. The results show that the synthesized scaffolds possess a three-dimensional porous structure. GO slightly improves the hydrophilicity of the scaffolds and reinforces their mechanical strength. Young’s modulus of the 1.5 wt% GO incorporated scaffold is greatly increased compared to the control sample. The in vitro experiments show that the nHAC/PLGA/GO (1.5 wt%) scaffolds significantly cell adhesion and proliferation of osteoblast cells (MC3T3-E1). This present study indicates that the nHAC/PLGA/GO scaffolds have excellent cytocompatibility and bone regeneration ability, thus it has high potential to be used as scaffolds in the field of bone tissue engineering.

Published in Nanoscale Research Letters

ISSN: 1931-7573 (Print); 1556-276X (Online)
Publisher: SpringerOpen
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.springer.com/journal/11671

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