Nature Communications (Dec 2018)

Structure of transcribing RNA polymerase II-nucleosome complex

  • Lucas Farnung,
  • Seychelle M. Vos,
  • Patrick Cramer

DOI
https://doi.org/10.1038/s41467-018-07870-y
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 6

Abstract

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Eukaryotic transcription requires passage of RNA polymerase II (Pol II) through chromatin, which is impaired by nucleosomes. Here the authors report the cryo-EM structure of transcribing Pol II engaged with a downstream nucleosome core particle at an overall resolution of 4.4 Å, providing insights into the mechanism of chromatin transcription.