Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy

Tuying Yong; Xiaoqiong Zhang; Nana Bie; Hongbo Zhang; Xuting Zhang; Fuying Li; Abdul Hakeem; Jun Hu; Lu Gan; Hélder A. Santos; Xiangliang Yang

doi:10.1038/s41467-019-11718-4

Nature Communications (Aug 2019)

Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy

Tuying Yong,
Xiaoqiong Zhang,
Nana Bie,
Hongbo Zhang,
Xuting Zhang,
Fuying Li,
Abdul Hakeem,
Jun Hu,
Lu Gan,
Hélder A. Santos,
Xiangliang Yang

Affiliations

Tuying Yong: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology
Xiaoqiong Zhang: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology
Nana Bie: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology
Hongbo Zhang: Pharmaceutical Sciences Laboratory and Turku Center for Biotechnology, Åbo Akademi University
Xuting Zhang: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology
Fuying Li: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology
Abdul Hakeem: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology
Jun Hu: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology
Lu Gan: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology
Hélder A. Santos: Drug Research Program, Division of Pharmaceutical Chemistry and Technology, University of Helsinki
Xiangliang Yang: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology

DOI: https://doi.org/10.1038/s41467-019-11718-4
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

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The generation of biomimetic nanoparticles that retain the integrity of proteins has been a challenge. Here, the authors generate biomimetic nanoparticles that are exocytosed from tumour cells and show their therapeutic potential in targeting tumours and cancer stem cells in multiple mouse models.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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