The Challenge of Hemorrhagic Shock Management During Low-Molecular-Weight Heparin Treatment

Abstract

Alessandro Morotti, Enrica Branca, Angelo Guerrasio Department of Clinical and Biological Sciences, University of Turin, Orbassano, ItalyCorrespondence: Alessandro MorottiDepartment of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, Orbassano 10043, ItalyEmail [email protected]: The reversal of low-molecular-weight heparin (LMWH) and the management of bleeding patients on LMWH remain highly challenging. Even if LMWH is very extensively administered in the prophylaxis and treatment of venous thrombosis, specific antidotes are lacking, and reversal strategies have very weak grade of evidences on clinical effectiveness. We here describe a reversal strategy with protamine and FVIIa in a patient presenting with hemorrhagic shock and cardiocirculatory arrest.Keywords: LMWH bleeding, LMWH reversal, FVIIa, protamine, mantle lymphoma

Keywords

• lmwh bleeding
• lmwh reversal
• fviia
• protamine
• mantle lymphoma