Oral immune dysfunction is associated with the expansion of FOXP3+PD-1+Amphiregulin+ T cells during HIV infection

N. Bhaskaran; E. Schneider; F. Faddoul; A. Paes da Silva; R. Asaad; A. Talla; N. Greenspan; A. D. Levine; D. McDonald; J. Karn; M. M. Lederman; P. Pandiyan

doi:10.1038/s41467-021-25340-w

Nature Communications (Aug 2021)

Oral immune dysfunction is associated with the expansion of FOXP3+PD-1+Amphiregulin+ T cells during HIV infection

N. Bhaskaran,
E. Schneider,
F. Faddoul,
A. Paes da Silva,
R. Asaad,
A. Talla,
N. Greenspan,
A. D. Levine,
D. McDonald,
J. Karn,
M. M. Lederman,
P. Pandiyan

Affiliations

N. Bhaskaran: Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University
E. Schneider: Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University
F. Faddoul: Advanced Education in General Dentistry, School of Dental Medicine, Case Western Reserve University
A. Paes da Silva: Department of Periodontics, School of Dental Medicine, Case Western Reserve University
R. Asaad: University Hospitals Cleveland Medical Center AIDS Clinical Trials Unit, Division of Infectious Diseases & HIV Medicine
A. Talla: Department of Pathology, School of Medicine, Case Western Reserve University
N. Greenspan: Department of Pathology, School of Medicine, Case Western Reserve University
A. D. Levine: Department of Microbiology and Molecular Biology, School of Medicine, Case Western Reserve University
D. McDonald: Division of AIDS, NIAID, NIH
J. Karn: Department of Microbiology and Molecular Biology, School of Medicine, Case Western Reserve University
M. M. Lederman: University Hospitals Cleveland Medical Center AIDS Clinical Trials Unit, Division of Infectious Diseases & HIV Medicine
P. Pandiyan: Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University

DOI: https://doi.org/10.1038/s41467-021-25340-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Anti-retroviral treatment does not fully resolve mucosal dysfunction and systemic inflammation in HIV infected individuals. Authors show here that an unusual population of regulatory T cells, distinguished by Amphiregulin expression and the incapability to suppress CD4 T cells might contribute to disrupted oral immune protection in HIV patients.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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