Communications Biology (Aug 2021)

Auto-inhibitory intramolecular S5/S6 interaction in the TRPV6 channel regulates breast cancer cell migration and invasion

  • Ruiqi Cai,
  • Lingyun Wang,
  • Xiong Liu,
  • Marek Michalak,
  • Jingfeng Tang,
  • Ji-Bin Peng,
  • Xing-Zhen Chen

DOI
https://doi.org/10.1038/s42003-021-02521-3
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 13

Abstract

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Cai et al discover an auto-inhibitory interaction between the S5 and S6 helices in the calcium-selective channel TRPV6. Molecular dynamics simulations predict that pathogenic mutation R532Q in S5 results in channel gain-of-function, which is confirmed in breast cancer migration, invasion and apoptosis assays.