Nature Communications (Oct 2019)
Anatomy and function of the vertebral column lymphatic network in mice
- Laurent Jacob,
- Ligia Simoes Braga Boisserand,
- Luiz Henrique Medeiros Geraldo,
- Jose de Brito Neto,
- Thomas Mathivet,
- Salli Antila,
- Besma Barka,
- Yunling Xu,
- Jean-Mickael Thomas,
- Juliette Pestel,
- Marie-Stéphane Aigrot,
- Eric Song,
- Harri Nurmi,
- Seyoung Lee,
- Kari Alitalo,
- Nicolas Renier,
- Anne Eichmann,
- Jean-Leon Thomas
Affiliations
- Laurent Jacob
- Université Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière
- Ligia Simoes Braga Boisserand
- Department of Neurology, Yale University School of Medicine
- Luiz Henrique Medeiros Geraldo
- INSERM U970, Paris Cardiovascular Research Center
- Jose de Brito Neto
- Université Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière
- Thomas Mathivet
- INSERM U970, Paris Cardiovascular Research Center
- Salli Antila
- Wihuri Research Institute and Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki
- Besma Barka
- Université Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière
- Yunling Xu
- INSERM U970, Paris Cardiovascular Research Center
- Jean-Mickael Thomas
- Ecole Nationale Supérieure d’Art de la Villa Arson
- Juliette Pestel
- Université Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière
- Marie-Stéphane Aigrot
- Université Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière
- Eric Song
- Department of Immunology, Yale University School of Medicine
- Harri Nurmi
- Wihuri Research Institute and Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki
- Seyoung Lee
- Department of Neurology, Yale University School of Medicine
- Kari Alitalo
- Wihuri Research Institute and Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki
- Nicolas Renier
- Université Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière
- Anne Eichmann
- INSERM U970, Paris Cardiovascular Research Center
- Jean-Leon Thomas
- Université Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière
- DOI
- https://doi.org/10.1038/s41467-019-12568-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
The lymphatic vasculature is essential to maintain fluid homeostasis and immune surveillance, including in the brain where lymphatic vessels were only recently identified. Here, Jacob et al. provide an anatomical map of lymphatic vessels in the vertebral column, where they find these contribute to fluid drainage and immune responses.
