New Phenylpropanoid and Coumarin Glycosides from the Stems of Hydrangea paniculata Sieb

Abstract

A new phenylpropanoid glycoside (1), and two new coumarin glycosides (2, 3), together with two known compounds (4, 5), have been isolated from the stems of Hydrangea paniculata Sieb. Their structures have been determined by spectroscopic and chemical methods. Furthermore, compound 1 (50 μM) exhibited significant hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced HepG2 cell damage in vitro assays.

Keywords

• Hydrangea paniculata
• phenylpropanoid glycoside
• coumarin glycoside
• hepatoprotective activity