Two new coordination polymers: Magnetic properties and treatment activity on non-small cell lung cancer by reversing the resistance of the cancer cells

Abstract

In the current study, by employing 5-((4-carboxypyridin-2-yl)amino)isophthalic acid (H3L), a semirigid carboxylate-pyridine ligand with V-shape, two new transition metal coordination polymers with the chemical formulae of [Cu1.5(L)(H2O)]·2H2O (1) and [Co4(L)2(CH3CN)(OH)2(H2O)4]·3H2O (2) have been successfully prepared through the reaction between the H3L ligand and corresponding metal salts under the solvothermal reaction conditions. Magnetic investigations have suggested that there is antiferromagnetic coupling between neighboring metal ions in the two compounds. The application values of compounds 1 and 2 on the non-small cell lung cancer (NSCLC) was evaluated and the related mechanism was discussed at the same time. First of all, the Cell Counting Kit-8 (CCK-8) detection kit was performed to measure the viability of the non-small cell lung cancer cells after compound treatment. In addition to this, the real time reverse transcription polymerase chain reaction (real time RT-PCR) was used to detect the relative expression levels of the ezh2 gene in NSCLC cells after indicated treatment.

Keywords

• Coordination complexes
• Magnetic properties
• NSCLC
• RT-PCR