Nature Communications (Aug 2016)
PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis
- Katherine Martin,
- James Pritchett,
- Jessica Llewellyn,
- Aoibheann F. Mullan,
- Varinder S. Athwal,
- Ross Dobie,
- Emma Harvey,
- Leo Zeef,
- Stuart Farrow,
- Charles Streuli,
- Neil C. Henderson,
- Scott L. Friedman,
- Neil A. Hanley,
- Karen Piper Hanley
Affiliations
- Katherine Martin
- Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences Centre
- James Pritchett
- Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences Centre
- Jessica Llewellyn
- Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences Centre
- Aoibheann F. Mullan
- Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences Centre
- Varinder S. Athwal
- Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences Centre
- Ross Dobie
- MRC Centre for Inflammation Research, The Queen’s Medical Research Institute, University of Edinburgh
- Emma Harvey
- Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences Centre
- Leo Zeef
- Bioinformatics Core Facility, Faculty of Life Sciences, University of Manchester
- Stuart Farrow
- Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences Centre
- Charles Streuli
- Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester
- Neil C. Henderson
- MRC Centre for Inflammation Research, The Queen’s Medical Research Institute, University of Edinburgh
- Scott L. Friedman
- Division of Liver Diseases, Icahn School of Medicine at Mount Sinai
- Neil A. Hanley
- Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences Centre
- Karen Piper Hanley
- Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences Centre
- DOI
- https://doi.org/10.1038/ncomms12502
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 11
Abstract
Antifibrotic therapies that target myofibroblast activation are needed to treat chronic liver disease. Here the authors identify an axis of integrin beta-1 expression and Yap-1 and Pak protein signalling that can be interfered with to inhibit myofibroblast function and liver fibrosis in vivo.
