Universal scanning-free initiation of eukaryote protein translation–a new normal

Abstract

A unique feature of eukaryote initiation of protein translation is a so-called scanning of 5′-untranslated region (5′-UTR) by a ribosome initiation complex to enable bound Met-tRNAi access to the initiation codon located further downstream. Here, we propose a universal scanning-free translation initiation model that is independent of 5′-UTR length and applicable to both 5′-m7G (capped) and uncapped mRNAs.

Keywords

• 5′-untranslated region
• eukaryote
• ribosome translation initiation complex
• ribosome scanning
• translation initiation site